Eyesiu Medicines and Eyesiu Care: a Leiden Bio Science Park company that creates innovative food supplements and therapeutics based on advanced delivery technology for compounds that support its users to maintain a pain-free lifestyle and healthier brains, eyes, lungs, skin and hair.
The Eyesiu Medicines division has prescription therapeutics in preclinical development based on cyclosporine A for patients, using the company's innovative and proprietary nanotechnology.
The products of Eyesiu Care are based on PEA (palmitoylethanolamide, N-(2-Hydroxyethyl)hexadecanamide, C18H37NO2, 299.499 gmol−1, logP 5.796, CAS Number: 544-31-0). PEA is an endogenous fatty acid amide, belonging to the class of nuclear factor agonists. PEA has been demonstrated to bind to a receptor in the cell-nucleus (a nuclear receptor) and exerts a great variety of biological supportive functions to maintain a pain-free lifestyle and healthier brains, eyes, lungs, skin and/or hair. The main target is thought to be the peroxisome proliferator-activated receptor alpha (PPAR-α). PEA also has affinity to TRPV1, GPR55 and GPR119, and lacks affinity for the cannabinoid receptors CB1 and CB2.
PEA is marketed as food supplement for human and veterinary use, in the form of capsules, sachets, chow (for dogs), creams, liposomes and liquids (in alcohol), none of which have instant effective delivery and/or pleasing presentation / taste. To date, no lipid-based sublingual, skin and mouth spray formulation for convenient, effective, sustained and instant delivery was available. Eyesiu Care’s novel and patented 2 mg/mL
PEArlboost PEA spray formulation fills that unmet need, and is for sale now. Furthermore, the fast-acting PEA spray is combined with the essential
nicotinamide (vitamin B3) and the powerful
huperzine A.